Loss of T Cell CD98 H Chain Specifically Ablates T Cell Clonal Expansion and Protects from Autoimmunity
نویسندگان
چکیده
منابع مشابه
Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity.
CD98 H chain (4F2 Ag, Slc3a2) was discovered as a lymphocyte-activation Ag. Deletion of CD98 H chain in B cells leads to complete failure of B cell proliferation, plasma cell formation, and Ab secretion. In this study, we examined the role of T cell CD98 in cell-mediated immunity and autoimmune disease pathogenesis by specifically deleting it in murine T cells. Deletion of T cell CD98 prevented...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2011
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1100002